Citation

Hildebrand CA, Hartmann AG, Arcinue EL, Gomez RJ, Bing RJ. Crit. Care Med. 1988; 16(4): 331-335.

Affiliation

Pediatric Intensive Care Unit, Huntington Memorial Hospital, Pasadena, CA 91105.

Copyright

(Copyright © 1988, Society of Critical Care Medicine, Publisher Lippincott Williams and Wilkins)

DOI

unavailable

PMID

3127119

Abstract

Between July 1985 and December 1986, 29 near-drowned children ranging in age between 6 months and 13 yr were admitted to the Pediatric ICU of Huntington Memorial Hospital. Eight patients suffered cardiopulmonary arrest and had an admission Glasgow Coma Score of 3 or 4. Hemodynamic monitoring was performed on five of these patients. Three received cerebral resuscitation with controlled hyperventilation, hypothermia, pentobarbital, and mannitol because of intracranial hypertension. After CPR, a low cardiac index (CI) and high systemic vascular resistance index (SVRI) were found. When cerebral resuscitative therapy was initiated later, it caused a reduction of SVRI, CI, mean arterial pressure, and cerebral perfusion pressure. Fluid volume therapy and inotropic cardiac support was necessary to maintain adequate cerebral perfusion pressure. These observations indicate that cerebral resuscitative therapy can affect cardiovascular function. The hemodynamic depressive effects might even worsen the outcome. For this reason, it is advisable to obtain CI and pulmonary capillary wedge pressure to optimize cerebral perfusion and potentially neurologic outcome.

Language: en