Citation

Yakovlev AG, Faden AI. J. Neurotrauma 1995; 12(5): 767-777.

Affiliation

Georgetown University Medical Center, Washington, DC 20007-2197, USA.

Copyright

(Copyright © 1995, Mary Ann Liebert Publishers)

DOI

unavailable

PMID

8594206

Abstract

Traumatic or ischemic injuries to the central nervous system (CNS) initiate reactive biochemical changes, some of which are autodestructive and others neuroprotective. Identification of these endogenous factors and their regulation will help to clarify mechanisms of secondary tissue damage and may lead to novel therapies. Recently developed molecular approaches offer opportunities for identifying genes involved in these reactive processes. Three types of molecular strategies are reviewed and examples are provided to demonstrate how each may be applied to elucidate basic mechanisms underlying posttraumatic or postischemic death.

Language: en