Citation

Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N. Circ. J. 2011; 75(4): 911-918.

Affiliation

Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine.

Copyright

(Copyright © 2011, Japanese Circulation Society)

DOI

unavailable

PMID

21372407

Abstract

Background: Normative alcohol use (or drinking behavior) influences the risk of cardiovascular disease in a multi-faceted manner. To identify susceptibility gene variants for drinking behavior, a 2-staged genome-wide association study was performed in a Japanese population. Methods and Results: In the stage-1 scan, 733 cases and 729 controls were genotyped with 456,827 SNP markers. The associated loci without redundancy of linkage disequilibrium were further examined in the stage-2 general population panel comprising 2,794 drinkers (≥once per week), 1,521 chance drinkers (

Language: en