Citation

Calabrese EJ. Crit. Rev. Toxicol. 2001; 31(4-5): 553-561.

Affiliation

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu

Copyright

(Copyright © 2001, Informa - Taylor and Francis Group)

DOI

10.1080/20014091111820

PMID

11504181

Abstract

This article briefly summarizes the occurrence of biphasic dose-response relationships associated with 5-hydroxytryptamine (5-HT) receptor systems, as well as 5-HT agonists and antagonists. Such biphasic responses have been reliably reported in multiple experimental settings that explored a broad range of responses, including aggressive behavior, cardiovascular functioning, muscle relaxation, and interactions with other receptor systems such as adrenergic interaction as well as with neurotransmitters such as NMDA.

Language: en