Citation

Haessler F, Glaser T, Beneke M, Pap AF, Bodenschatz R, Reis O. Br. J. Psychiatry 2007; 190: 447-448.

Affiliation

Department of Child and Adolescent Psychiatry, University of Rostock, Rostock, Germany. frank.haessler@med.uni-rostock.de

Copyright

(Copyright © 2007, Royal College of Psychiatry)

DOI

10.1192/bjp.bp.105.016535

PMID

17470962

Abstract

We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixolin this population leads to an increase in aggressive behaviour.

Language: en