Citation

Rudissaar R, Pruus K, Skrebuhhova-Malmros T, Allikmets L, Matto V. Methods Find. Exp. Clin. Pharmacol. 2000; 22(8): 637-640.

Affiliation

Department of Pharmacology, University of Tartu, Tartu, Estonia.

Copyright

(Copyright © 2000, Thomas Reuters)

DOI

unavailable

PMID

11256236

Abstract

The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.

Language: en