Citation

Alarcon RD, Johnson BR, Lucas JP. J. Am. Acad. Child Adolesc. Psychiatry 1991; 30(6): 999-1002.

Affiliation

Department of Psychiatry, University of Alabama Birmingham.

Copyright

(Copyright © 1991, American Academy of Child Adolescent Psychiatry, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/00004583-199111000-00020

PMID

1757451

Abstract

Obsessive-compulsive disorder is increasingly recognized in patients of different age groups. Serotonergic agents, such as clomipramine, have been recently found to be useful in the management of this condition. However, unexpected side effects, such as dysphoria, aggressiveness, and paranoid ideation, may occur with therapeutic doses of this compound, as evidenced in the cases of two male adolescents presented here. Possible pathogenetic factors, involving serotonin and serotonin-receptor abnormalities are discussed. Management of these side effects is based on adequate dose reduction and monitorization.

Language: en