Citation

Aronowski J, Zhao X. Stroke 2011; 42(6): 1781-1786.

Affiliation

From the Stroke Program, Department of Neurology, University of Texas Health Science Center at Houston, Medical School, Houston, TX.

Copyright

(Copyright © 2011, American Heart Association, Publisher Lippincott Williams and Wilkins)

DOI

10.1161/STROKEAHA.110.596718

PMID

21527759

PMCID

PMC3123894

Abstract

Intracerebral hemorrhage (ICH) is an often fatal type of stroke that kills ≈30 000 people annually in the United States. If the patient survives the ictus, then the resulting hematoma within brain parenchyma triggers a series of adverse events causing secondary insults and severe neurological deficits. This article discusses selected aspects of secondary brain injury after ICH and outlines key mechanisms associated with hematoma toxicity, oxidative stress, and inflammation. Finally, this review discusses the relevance of hematoma resolution processes as a target for ICH therapy and presents potential clinically relevant molecular targets that could be harnessed to treat secondary injury associated with ICH injury.

Language: en