Citation

Corbet A, Long W, Schumacher R, Gerdes J, Cotton R. J. Pediatr. 1995; 126(5 Pt 2): S5-12.

Affiliation

Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

Copyright

(Copyright © 1995, Elsevier Publishing)

DOI

unavailable

PMID

7745511

Abstract

Infants enrolled in three clinical trials of prophylactic treatment for respiratory distress syndrome with a single dose of synthetic surfactant (Exosurf Neonatal) or air placebo were monitored through 1-year adjusted age. A total of 1046 infants with birth weights from 500 to 1350 gm were enrolled in the three trials; of the 735 infants who survived to 1 year of age, follow-up evaluations were completed for 597 (80%, air placebo group; 82%, synthetic surfactant group). Infants in the air placebo and synthetic surfactant treatment groups had no differences in general health, growth, or nerodevelopmental outcomes or impairments. These follow-up results at 1-year adjusted age for infants who received a single dose of synthetic surfactant indicate that a single dose of synthetic surfactant reduces mortality without increasing the absolute number or proportion of infants with impairments at 1 year of age.

Language: en