Citation

Bender MA. Stem Cells 1995; 13(Suppl 1): 172-181.

Affiliation

Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA.

Copyright

(Copyright © 1995, John Wiley and Sons)

DOI

unavailable

PMID

7488943

Abstract

Radiation cytogenetics goes back approximately six decades and not only contributed to the earliest development of radiobiology, but continues to contribute today. Contributions on three levels are outlined here. Early contributions to radiobiological theory include the nature of dose-effect curves, dose-rate and fractionation effects, and linear energy transfer (LET) effects. Understanding of the roles of aberrations in endpoints such as cell killing, mutation and carcinogenesis have more recently contributed to unraveling mechanisms in these important radiobiological effects. Finally, the study of various details of classical radiation cytogenetics, such as half chromatid exchange or sister chromatid union, has contributed to our current understanding of cytogenetic phenomena on the molecular level.

Language: en