Citation

Ananda A, Morris GF, Juul N, Marshall SB, Marshall LF. Acta Neurochir. Suppl. 1999; 73: 99-102.

Affiliation

Department of Neurosurgery, University of Alabama Medical Center, Birmingham, USA.

Copyright

(Copyright © 1999, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

10494350

Abstract

Neurologic deterioration observed following head injury is recognized as having a deleterious effect on outcome. The present study examines this occurrence in detail to determine the frequency of these episodes, their antecedent events and causal relationships in order to identify patients who are at risk. Data was collected prospectively from a consecutive series of 427 patients entered into the international trial of the NMDA receptor antagonist Selfotel. Using a definition of neurologic worsening based upon objective criteria, 117 patients were identified who suffered 164 episodes of deterioration. The occurrence of a single episode of neurologic worsening increased mortality by more than five-fold and reduced favorable outcomes (good or moderate on the Glasgow Outcome Scale), by more than 50%. Increased intracranial volume resulting in intracranial hypertension was the single most frequent cause of neurologic worsening. This serves to emphasize the importance of more adequate treatments of intracranial hypertension in improving the outcome of patients with severe head injury.

Language: en