Citation

Castillo UF, Ojika M, Alonso-Amelot M, Sakagami Y. Bioorg. Med. Chem. 1998; 6(11): 2229-2233.

Affiliation

Department of Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.

Copyright

(Copyright © 1998, Elsevier Publishing)

DOI

unavailable

PMID

9881114

Abstract

Reversed-phase HPLC fractionation, monitored by brine shrimp bioassay, led to the isolation of a new illudane-type sesquiterpene glucoside, ptaquiloside Z (2), as well as the known bracken carcinogen ptaquiloside (1), from a bioactive aqueous extract of the neotropical bracken fern Pteridium aquilinum var. caudatum (Pteridaceae). The structure of ptaquiloside Z (2) was confirmed by spectroscopic analyses and chemical degradation. Both compounds exhibited similar toxicity (LC50 62.5 micrograms/ml at 24 h and LC50 7.8 micrograms/ml at 48 h) toward brine shrimp.

Language: en