Citation

Moeller FG, Allen T, Cherek DR, Dougherty DM, Lane S, Swann AC. Psychiatry Res. 1998; 81(1): 31-38.

Affiliation

Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA. moeller@msi13.msi.uth.tmc.edu

Copyright

(Copyright © 1998, Elsevier Publishing)

DOI

unavailable

PMID

9829648

Abstract

Thirty-one human subjects were administered a neuroendocrine challenge with the 5-HT1a agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP), in order to determine if a laboratory measure of aggression was related to serotonin function. Subjects who showed more aggressive responding on the PSAP (n = 11) had a significantly blunted temperature response to ipsapirone compared to those with less aggressive responding (n = 20). There was no difference between the two groups on the cortisol response to ipsapirone. This study supports a relationship between serotonin function and aggression as measured in the human laboratory, similar to the well-documented association between self-reported aggression and serotonin.

Language: en