Citation

Blom MW, Bartel PR, Sommers DK, Van der Meyden CH, Becker PJ. Fundam. Clin. Pharmacol. 1992; 6(1): 5-9.

Affiliation

Department of Pharmacology, University of Pretoria, South Africa.

Copyright

(Copyright © 1992, John Wiley and Sons)

DOI

unavailable

PMID

1555812

Abstract

This study compares the effects of buspirone (5 mg), chlordiazepoxide (5 mg), hydroxyzine (10 mg) and placebo on psychomotor function and EEG, when taken thrice daily for a period of two weeks, with those after a single dose administration. Nine healthy volunteers participated in the study. The battery of psychomotor tests included peak velocity of saccadic eye movements (SEM), a Sternberg memory scanning and choice reaction time test (SMS-CRT) and critical flicker fusion frequency (CFFF). The peak velocity of saccadic eye movements was significantly impaired by the single dose of hydroxyzine (P = 0.03) in comparison to the multidose results. A similar comparison regarding buspirone only approached significance (P = 0.07). The SMS-CRT and CFFF did not reveal any difference between the multi and single dose regimens. Spectral analysis of the EEG did not distinguish between the multi and single dosage schedules regarding the respective drugs in the low doses administered.

Language: en