Citation

Akpaffiong MJ, Ruiz P. Psychiatr. Q. 1991; 62(4): 299-309.

Affiliation

College of Pharmacy and Health Sciences, Texas Southern University, Houston.

Copyright

(Copyright © 1991, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

1687338

Abstract

One hundred and sixty psychiatric patients on Neuroleptics, with and without a history of substance abuse were daily monitored in order to establish the incidence of neuroleptic malignant syndrome in these two groups. Four (5.1%) of the cocaine abusers and none of the non-cocaine abusers developed neuroleptic malignant syndrome when treated with neuroleptics. Thus we argue that psychiatric patients with a history of cocaine abuse may be more at risk of developing neuroleptic malignant syndrome when treated with neuroleptics, possibly associated with the blockade of dopamine (D2-receptors) by neuroleptics and the activation of dopamine/5-HT receptors by cocaine-induced dopamine.

Language: en