Citation

Mao J, Pace E, Pierozynski P, Kou Z, Shen Y, Vandevord PJ, Haacke EM, Zhang X, Zhang J. J. Neurotrauma 2012; 29(2): 430-444.

Affiliation

Wayne State University, Otolaryngology, Detroit, Michigan, United States; johnnymao@msn.com.

Copyright

(Copyright © 2012, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2011.1934

PMID

21933015

PMCID

PMC3261792

Abstract

The current study used a rat model to investigate the underlying mechanisms of blast-induced tinnitus, hearing loss and associated traumatic brain injury (TBI). Seven rats were used to evaluate behavioral evidence of tinnitus and hearing loss, and TBI using magnetic resonance imaging following a single 10 ms blast at 14 psi or 194 dB SPL. The results demonstrated that the blast exposure induced early onset of tinnitus and central hearing impairment at a broad frequency range. The induced tinnitus and central hearing impairment tended to shift towards high frequencies over time. Hearing threshold measured with auditory brainstem responses also showed an immediate elevation followed by recovery on day 14, coinciding with behaviorally measured results. Diffusion tensor magnetic resonance imaging results demonstrated significant damage and compensatory plastic changes to certain auditory brain regions, with the majority of changes occurring in the inferior colliculus and medial geniculate body. No significant microstructural changes found in the corpus callosum indicates that the currently adopted blast exposure mainly exerts effects through the auditory pathways rather than through direct impact onto the brain parenchyma. The results showed that this animal model is appropriate for investigation of the mechanisms underlying blast-induced tinnitus, hearing loss and related TBI. Continued investigation along this line will help identify pathology with injury/recovery patterns, aiding development of effective treatment strategies.

Language: en