Citation

Di Paola M, Caltagirone C, Spalletta G. Expert Rev. Neurother. 2011; 11(11): 1557-1560.

Affiliation

Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179, Rome, Italy.

Copyright

(Copyright © 2011, Future Science Group)

DOI

10.1586/ern.11.130

PMID

22014133

Abstract

Evaluation of: Ryberg C, Rostrup E, Paulson OB et al. On behalf of the LADIS study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3 year follow-up of the LADIS study cohort. J. Neurol. Sci. 307(1-2), 100-105 (2011). The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.

Language: en