Citation

Snyder SH. Am. J. Psychiatry 1976; 133(2): 197-202.

Copyright

(Copyright © 1976, American Psychiatric Association)

DOI

unavailable

PMID

1251927

Abstract

Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones is associated with blockade of dopamine receptors, while exacerbation of symptoms by amphetamines appears to result from enhanced synaptic activity of dopamine and/or norepinephrine. The author suggests that biochemical labeling of the dopamine receptor with 3H-dopamine and 3H-haloperidol may clarify mechanisms of drug effects on the dopamine receptor.

Language: en