Citation

Prins ML, Hovda DA. J. Neurotrauma 2003; 20(2): 123-137.

Affiliation

Division of Neurosurgery, UCLA School of Medicine, Los Angeles, California 90095-7039, USA. mprins@mednet.ucla.edu

Copyright

(Copyright © 2003, Mary Ann Liebert Publishers)

DOI

10.1089/08977150360547053

PMID

12675967

Abstract

Traumatic brain injury (TBI) is the leading cause of injury-related death and disability among children under the age of 15 years in the United States. Epidemiological studies have revealed that even within the pediatric population there are differences in incidence, gender differences, causes, types of injuries sustained, and mortality within age subdivisions. This heterogeneity must be taken into account when developing appropriate models to address TBI in children. This review explores the current developmental TBI models, including fluid percussion, weight drop, and controlled cortical impact. It also addresses unique considerations to modeling pediatric brain injury that require special attention when modeling and designing studies: age appropriateness, injury severity, evaluation of recovery, plasticity, and anesthesia.

Language: en