Citation

Gurudutta GU, Satija NK, Singh VK, Verma YK, Gupta P, Tripathi RP. Indian J. Med. Res. 2012; 135(1): 15-25.

Affiliation

Stem Cell & Gene Therapy Research Group, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.

Copyright

(Copyright © 2012, Indian Council of Medical Research)

DOI

unavailable

PMID

22382178

PMCID

PMC3307178

Abstract

Stem cell therapy hold the potential to meet the demand for transplant cells/tissues needed for treating damages resulting from both natural and man-made disasters. Pluripotency makes embryonic stem cells and induced pluripotent stem cells ideal for use, but their teratogenic character is a major hindrance. Therapeutic benefits of bone marrow transplantation are well known but characterizing the potentialities of haematopoietic and mesenchymal cells is essential. Haematopoietic stem cells (HSCs) have been used for treating both haematopoietic and non-haematopoietic disorders. Ease of isolation, in vitro expansion, and hypoimmunogenecity have brought mesenchymal stem cells (MSCs) into limelight. Though differentiation of MSCs into tissue-specific cells has been reported, differentiation-independent mechanisms seem to play a more significant role in tissue repair which need to be addressed further. The safety and feasibility of MSCs have been demonstrated in clinical trials, and their use in combination with HSC for radiation injury treatment seems to have extended benefit. Therefore, using stem cells for treatment of disaster injuries along with the conventional medical practice would likely accelerate the repair process and improve the quality of life of the victim.

Language: en