Citation

Bayir H, Clark RSB, Kochanek PM. Crit. Care Med. 2003; 31(1 Suppl): S112-7.

Affiliation

Safar Center for Resuscitation Research and Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Copyright

(Copyright © 2003, Society of Critical Care Medicine, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/01.CCM.0000042464.46603.0E

PMID

12544985

Abstract

OBJECTIVE: To review novel therapeutic approaches in the treatment of severe traumatic brain injury. DESIGN: Eighty-three studies were reviewed specific to the treatment of traumatic brain injury, in either experimental models or in patients. CONCLUSION: Four therapeutic strategies appear to be the most promising approaches currently in clinical trials for severe traumatic brain injury: a) the novel pharmacologic agent dexanabinol; b) hypertonic saline; c) mild hypothermia; and d) decompressive craniectomy. Each of these therapies share the common feature of targeting multiple mechanisms, suggesting this may be an important factor to the development of a successful approach to severe traumatic brain injury.

Language: en