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Citation |
Zai CC, Muir KE, Nowrouzi B, Shaikh SA, Choi E, Berall L, Trépanier MO, Beitchman JH, Kennedy JL. Psychiatry Res. 2012; 200(2-3): 784-788. |
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Affiliation |
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada. |
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Copyright |
(Copyright © 2012, Elsevier Publishing) |
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DOI |
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PMID |
22910476 |
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Abstract |
Background: Studies on animal models have implicated arginine vasopressin signalling pathway in aggressive behaviour. The role of arginine vasopressin in childhood onset aggression is unclear. Methods: We investigated 11 single-nucleotide polymorphisms in the genes coding for arginine vasopressin and its receptors in our sample of 177 aggressive child cases paired with adult controls matched for sex and ethnicity. Results: We found the non-synonymous polymorphism AVPR1B_rs35369693 to be associated with child aggression in our sample (P=0.007). We also found two-marker haplotype window containing AVPR1B_rs35369693 and AVPR1B_rs28676508 to be associated (P=0.003). The haplotype findings survived multiple-testing adjusted significance threshold of 0.0063. Conclusions: This is the first report of a genetic association between vasopressin receptor 1B and child aggression. Replication in independent samples are required to confirm these findings. Language: en |