Citation

Malec D, Kotlińska J, Langwiński R. J. Stud. Alcohol 1987; 48(5): 507-510.

Affiliation

Department of Pharmacodynamics, Medical Academỳ, Lublin, Poland.

Copyright

(Copyright © 1987, Rutgers Center of Alcohol Studies)

DOI

unavailable

PMID

3669680

Abstract

Morphinization of mice (37.5 mg morphine) and rats (75 mg) with subcutaneously implanted pellets has resulted in tolerance to the antinociceptive effect of morphine, measured in the tail-immersion test. All animals also developed cross-tolerance to the analgesic effects of ethanol (2.8 g/kg intraperitoneally for mice, per os for rats). These results suggest a commonality between morphine and ethanol antinociceptive action.

Language: en