Citation

Rollin P, Antaki AJ. Can. Med. Assoc. J. 1979; 120(8): 951-956.

Vernacular Title

L'intoxication par antidépresseurs tricycliques chez l'enfant et l'adolescent.

Copyright

(Copyright © 1979, Canadian Medical Association)

DOI

unavailable

PMID

373877

PMCID

PMC1819262

Abstract

During the last decade there has been a substantial increase in the number of poisonings due to tricyclic antidepressants in both children and adults. The main toxic manifestations are of anticholinergic origin, and the most frequent constitute the so-called central anticholinergic syndrome. Most of the deaths result from the cardiac complications. Three cases are presented that illustrate chiefly the toxic manifestations related to the central nervous system. The therapeutic management is reviewed in the light of the metabolism of the tricyclic antidepressants, their pharmacologic action and the mechanism of their toxic effects.

Language: fr