Citation

Porto SK, Nogueira T, Blanes L, Doble P, Sabino BD, do Lago CL, Angnes L. J. Forensic Sci. 2014; 59(6): 1622-1626.

Affiliation

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05508-000, São Paulo, SP, Brazil; Serviço de Perícias de Química, Instituto de Criminalística Carlos Éboli, R. Pedro I, 28, Rio de Janeiro, RJ, Brazil.

Copyright

(Copyright © 2014, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

10.1111/1556-4029.12573

PMID

25039689

Abstract

A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4) D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-C(4) D and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C(4) D instead of traditional CE-UV methods for in-field analysis are also discussed.

Language: en