Citation

Aslaksen A, Aanderud L. Br. J. Clin. Pharmacol. 1980; 10(4): 383-385.

Copyright

(Copyright © 1980, John Wiley and Sons)

DOI

unavailable

PMID

7448109

PMCID

PMC1430093

Abstract

1 The effect of exercise on the absorption of quinidine sulphate, sodium salicylate and sulphadimidine was studied in healthy volunteers. 2 The study was a randomized cross-over design with work and rest. The work load was 450 kpm/min for females and 600 kpm/min for males on a bicycle ergometer intermittently for 3 h. 3 The plasma concentrations of the drugs were followed during the entire experiment and their respective peak concentrations (Cmax) and time to peak (tmax) were determined. 4 No significant differences in the Cmax and tmax were found between rest and work for any of the drugs. 5 The results suggest that physical exercise is not a major source of variation in drug absorption.

Language: en