Citation

Mathis RD, Walker JS, Kuhns DW. J. Emerg. Med. 1988; 6(1): 37-40.

Affiliation

Department of Emergency Medicine, Darnall Army Community Hospital, Fort Hood, Texas.

Copyright

(Copyright © 1988, Elsevier Publishing)

DOI

unavailable

PMID

3283215

Abstract

A case of acetaminophen poisoning following the ingestion of 26 g of acetaminophen by incremental dosing over a 25-h period is reported. At presentation, seven h after the last ingestion, the patient experienced hematemesis, the acetaminophen level was 150 micrograms/mL, and the SGOT was normal. The patient recovered uneventfully following N-acetylcysteine therapy. A review of the pharmacology and toxicity of acetaminophen is discussed. The case illustrates the problems of judging hepatotoxic potential in a multiple-dose acetaminophen ingestion and describes the successful use of N-acetylcysteine in a patient with a "subacute" acetaminophen overdose.

Language: en