Citation

Jovanovic D. Arch. Toxicol. 1989; 63(5): 416-418.

Affiliation

Military Technical Institute, Medical Department, Belgrade, Yugoslavia.

Copyright

(Copyright © 1989, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

2818204

Abstract

The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides. The elevation of plasma concentrations of the oxime and prolongation of its "effective half-life" were noticed in poisoned individuals. These changes were attributed to the disturbed general hemodynamics and reduced renal blood flow in organophosphorus intoxication rather than to the direct renal toxicity of anticholinesterases.

Language: en