Citation

Curley P, Abbott R, Vallance D. Br. J. Neurosurg. 1989; 3(6): 655-658.

Affiliation

Department of Surgery, Leicester Royal Infirmary.

Copyright

(Copyright © 1989, Informa - Taylor and Francis Group)

DOI

unavailable

PMID

2627284

Abstract

The clinical value of serum brain specific creatine kinase (CK-BB) was assessed in head injured patients (group A) using a new enzyme-linked immunosorbent assay (ELISA). The results were compared to healthy controls (group B) and patients post-myocardial infarction (group C). None of the head injured patients had undergone a surgical procedure or ventricular puncture. CK-BB was significantly higher in group A than in controls. The level of CK-BB in group A was inversely proportional to the Glasgow Coma Scale on admission. All patients with a CK-BB greater than 100 micrograms/l died. The ELISA technique is a simple and reliable assay with prognostic significance in patients with head injury and has wider clinical application than the previously described radioimmunoassay methods.

Language: en