Citation

Ilchibaeva TV, Kondaurova EM, Tsybko AS, Kozhemyakina RV, Popova NK, Naumenko VS. Behav. Brain Res. 2015; 290: 45-50.

Affiliation

Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia. Electronic address: naumenko2002@bionet.nsc.ru.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.bbr.2015.04.041

PMID

25934485

Abstract

The brain-derived neurotrophic factor (BDNF), its precursor (proBDNF) and BDNF mRNA levels were studied in the brain of wild rats selectively bred for more than 70 generations for either high level or for the lack of affective aggressiveness towards man. Significant increase of BDNF mRNA level in the frontal cortex and increase of BDNF level in the hippocampus of aggressive rats was revealed. In the midbrain and hippocampus of aggressive rats proBDNF level was increased, whereas BDNF/proBDNF ratio was reduced suggesting the prevalence and increased influence of proBDNF in highly aggressive rats. In the frontal cortex, proBDNF level in aggressive rats was decreased. Thus, considerable structure-specific differences in BDNF and proBDNF levels as well as in BDNF gene expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of BDNF and its precursor proBDNF in the mechanism of aggressiveness and in the creation of either aggressive or nonaggressive phenotype.

Language: en