Citation

Zagorchev L, Meyer C, Stehle T, Wenzel F, Young S, Peters J, Weese J, Paulsen KD, Garlinghouse M, Ford J, Roth R, Flashman LA, McAllister T. J. Neurotrauma 2015; 33(1): 29-34.

Affiliation

Philips Research North America, Briarcliff Manor, New York, United States, Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States ; lyubomir.zagorchev@philips.com.

Copyright

(Copyright © 2015, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2014.3831

PMID

25970552

Abstract

Conventional structural imaging is often normal after mild Traumatic Brain Injury (mTBI). There is a need for structural neuroimaging biomarkers that facilitate detection of milder injuries, allow recovery trajectory monitoring, and identify those at risk for poor functional outcome and disability. We present a novel approach to quantifying volumes of candidate brain regions at risk for injury. Compared to controls, mTBI patients had significantly smaller volumes in several regions including the caudate, putamen, and thalamus when assessed two months after injury. These differences persisted but were reduced in magnitude one year after injury, suggesting the possibility of normalization over time in the affected regions. However more pronounced differences were found in the amygdala and hippocampus suggesting the possibility of regionally specific responses to injury.

Language: en