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Abstract
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AIM: In the present study, our aim was to investigate the oxidative - antioxidative systems in unmedicated first episode psychosis (FEP) patients at the beginning and after short term treatment.
METHODS: This study consisted of 29 patients who experienced a FEP and 25 control subjects. In order to investigate the oxidative status, we determined plasma malondialdehyde (MDA) levels, oxidizability of red blood cells, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (apo B-basal MDA and apo B-ΔMDA). And to evaluate the antioxidative defense we measured serum total antioxidative capacity, uric acid, albumin, total bilirubin and vitamin E levels and serum paraoxonase/arylesterase, whole blood glutathione peroxidase (GPx) and red blood cell superoxide dismutase (RBC-SOD) activities before and after 6-weeks of treatment in patients with FEP.
RESULTS: Plasma MDA and apo B-basal MDA levels and RBC-SOD activity were significantly higher and serum arylesterase and whole blood-GPx activities were lower in the FEP group than those of the healthy control group. There wee not any significant changes in the oxidative and antioxidative system parameters (except increased vitamin E levels) after treatment.
CONCLUSION: The results of this study suggest that FEP is accompanied with oxidative stress. However, further studies are needed to clarify the role of oxidative stress in the physiopathological mechanisims of FEP, so that oxidative and antioxidative system parameters can be used in the management of these patients. In accordance with psychiatric evaluation, for a better management, patients with FEP may require a multidisciplinary approach including oxidative and antioxidative system parameters.
Language: en |