Citation

Sublette ME, Vaquero C, Baca-Garcia E, Pachano G, Huang YY, Oquendo MA, Mann JJ. Psychiatr. Genet. 2015; 26(2): 81-86.

Affiliation

Departments of aPsychiatry bRadiology, Columbia University cDepartment of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, New York, USA dDepartment of Psychiatry, IIS Fundación Jiménez-Díaz Madrid eDepartment of Psychiatry, Universidad Autonoma de Madrid fCIBERSAM (Centro de Investigación en Salud Mental), Institute of Health Carlos III of Madrid, Madrid, Spain.

Copyright

(Copyright © 2015, Lippincott Williams and Wilkins)

DOI

10.1097/YPG.0000000000000111

PMID

26513616

Abstract

Fatty acid desaturase genes (FADS1-FADS2) encode desaturases participating in the biosynthesis of long-chain polyunsaturated fatty acids. As long-chain polyunsaturated fatty acids are implicated in major depressive disorder (MDD) and suicide risk, and as both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls) and suicide attempt status (291 attempters, 344 MDD nonattempters). Eighteen FADS-related single-nucleotide polymorphisms were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324) and entered as predictors into logistic regression analyses with diagnostic group or suicide attempt history as outcomes and location and sex as covariates. No associations were observed between any single-nucleotide polymorphisms and diagnosis or attempt status. As statistical power was adequate, we conclude that FADS1-FADS2 genetic variants may not be a common determinant of MDD.

Language: en