Citation

Baldessarini RJ, Tondo L, Visioli C, Vazquez GH. J. Affect. Disord. 2015; 191: 118-122.

Affiliation

International Consortium for Psychotic and Mood Disorders Research, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States; Department of Neurosciences, Palermo University, Buenos Aires, Argentina.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.jad.2015.10.058

PMID

26655121

Abstract

BACKGROUND: There is suggestive evidence that prior illness history may have little association with response to long-term treatment in bipolar disorder (BD) or recurrent major depressive disorder (MDD), but relationships of illness-history to treatment-response in acute episodes of depression require further testing.

METHODS: We tested for associations of selected measures of illness history with remission during treatment of an acute index episode of major depression in 515 mood-disorder patients (327 MDD, 188 BD), using bivariate and multivariate methods.

RESULTS: Remission of depression was more likely with lesser initial symptom-severity and bipolar diagnosis, but not related to years since illness-onset, previous depressions or episodes (based on counts, yearly rates, or %-of months ill), or other indices of illness-severity (hospitalization, co-morbidity, suicide attempt).

CONCLUSIONS: Likelihood of response to standard treatments for acute major depressive episodes in MDD or BD appeared to be largely independent of prior illness-history.

Language: en