Citation

Molina PE, Katz PS, Souza-Smith F, Ford SM, Teng SX, Dodd TY, Maxi JK, Mayeux JP. Alcohol Res. 2015; 37(2): 263-278.

Affiliation

Department of Physiology, Comprehensive Alcohol Research Center and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Copyright

(Copyright © 2015, National Institute on Alcohol Abuse and Alcoholism (USA))

DOI

unavailable

PMID

26695749

PMCID

PMC4590622

Abstract

Alcohol consumption contributes to increased incidence and severity of traumatic injury. Compared with patients who do not consume alcohol, alcohol-consuming patients have higher rates of long-term morbidity and mortality during recovery from injury. This can be attributed in part to an impaired immune response in individuals who consume alcohol. Acute and chronic alcohol use can affect both the innate and adaptive immune defense responses within multiple organ systems; the combination of alcohol use and injury results in increased susceptibility to bacterial and viral pathogens. This review examines the major deleterious effects of alcohol on immunity following tissue damage or traumatic injury, with a focus on alcohol's influence on the ability of the immune and major organ systems to fight disease and to repair damaged tissues following injury.

Language: en