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Citation
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Jalenques I, Rondepierre F, Massoubre C, Haffen E, Grand JP, Labeille B, Perrot JL, Aubin F, Skowron F, Mulliez A, D'Incan M. Br. J. Dermatol. 2016; 174(5): 1051-1060. |
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Affiliation
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Université d'Auvergne, CHU Clermont-Ferrand, service de Dermatologie, 63000, Clermont-Ferrand, France. |
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Abstract
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BACKGROUND: Psychiatric disorders have been extensively documented in patients with systemic lupus erythematosus. However, the prevalence of psychiatric disorders in skin-restricted lupus (SRL) patients remains unknown although SRL is more common than SLE.
OBJECTIVES: To assess current and lifetime prevalence of Axis I psychiatric disorders among SRL outpatients and to examine the factors associated with psychiatric disorders among such patients.
METHODS: Multicentre case-control study involving SRL outpatients and controls matched for sex, age and education level. Mini International Neuropsychiatric Interview was used for psychiatric evaluation.
RESULTS: We evaluated 75 patients and 150 controls: 49% of patients vs 13% of controls fulfilled the criteria for at least one current psychiatric disorder (p<0.001). The following disorders were significantly more frequent among patients than controls: current and lifetime major depressive disorder (9% vs 0% p = 0.0007 and 44% vs 26% p = 0.01), generalized anxiety disorder (23% vs 3% p<0.001 and 35% vs 19% p = 0.03), panic disorder (7% vs 0% p = 0.004 and 21% vs 3% p<0.001), current suicide risk (24% vs 7% p = 0.003), alcohol dependence (7% vs 0% p = 0.004), and lifetime agoraphobia (20% vs 9% p = 0.01). Lupus duration and lupus past treatment by thalidomide were significantly higher among patients with current psychiatric disorders.
CONCLUSIONS: This study demonstrates a high prevalence of several psychiatric disorders (anxiety, depression, suicide risk, alcohol dependence) in SRL patients. This article is protected by copyright. All rights reserved.
Language: en |