Citation

van den Heuvel L, Suliman S, Malan-Müller S, Hemmings S, Seedat S. Anxiety Stress Coping 2016; 29(6): 616-629.

Affiliation

Department of Psychiatry, Faculty of Medicine and Health Sciences , University of Stellenbosch , Cape Town , South Africa.

Copyright

(Copyright © 2016, Informa - Taylor and Francis Group)

DOI

10.1080/10615806.2016.1163545

PMID

26999419

Abstract

BACKGROUND: Alterations in brain-derived neurotrophic factor (BDNF) expression and release may play a role in the pathogenesis of posttraumatic stress disorder (PTSD).

DESIGN: This study evaluated road traffic accident (RTA) survivors to determine whether PTSD and trauma related factors were associated with plasma BDNF levels and BDNF Val66Met carrier status following RTA exposure.

METHODS: One hundred and twenty-three RTA survivors (mean age 33.2, SD = 10.6 years; 56.9% male) were assessed 10 (SD = 4.9) days after RTA exposure. Acute stress disorder (ASD), as assessed with the Acute Stress Disorder Scale (ASDS), was present in 50 (42.0%) of the participants. Plasma BDNF levels were measured with enzyme-linked immunosorbent assay (ELISA) and BDNF Val66Met genotyping was performed. PTSD, as assessed with the Clinician-Administered PTSD Scale (CAPS), was present in 10 (10.8%) participants at 6 months follow-up.

RESULTS: Neither BDNF Val66Met genotype nor plasma BDNF was significantly associated with the presence or severity of ASD or PTSD. Plasma BDNF levels were, however, significantly correlated with the lifetime number of trauma exposures.

CONCLUSIONS: In RTA survivors plasma BDNF levels increased with increasing number of prior trauma exposures. Plasma BDNF may, therefore, be a marker of trauma load.

Language: en