Citation

Patrani M, Tsaganos T, Kotzampassi K, Paraschos M, Katsenos C, Giamarellos-Bourboulis EJ, Mandragos K. Biomarkers 2016; 21(7): 660-664.

Affiliation

a Intensive Care Unit, Korgialeneion Benakeion General Hospital , Athens , Greece ;

Copyright

(Copyright © 2016, Informa - Taylor and Francis Group)

DOI

10.3109/1354750X.2016.1171911

PMID

27121128

Abstract

PURPOSE: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas.

METHODS: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset.

RESULTS: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis.

CONCLUSIONS: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas.

Language: en