Citation

Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Karnecki K, Jankowski Z, Gos T. Psychiatry Res. 2016; 241: 43-46.

Affiliation

Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland; Department of Psychiatry, Otto-von-Guericke-University, Magdeburg, Germany; Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto-von-Guericke-University, Magdeburg, Germany. Electronic address: gost@gumed.edu.pl.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.psychres.2016.04.079

PMID

27155286

Abstract

The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour. We have evaluated the transcriptional activity of ribosomal DNA (rDNA) in DRN neurons by AgNOR silver staining method. The cohort (containing 24 suicidal and 20 non-suicidal patients, and 28 controls) was previously analysed regarding diagnosis-related differences between schizophrenia and affective disorders. Significant decreases in both AgNOR and nuclear areas suggestive of attenuated rDNA activity were currently found in suicidal versus non-suicidal patients. This effect, which was more accentuated in affective disorders patients, was not explained by antidepressant and antipsychotic medication.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Language: en