Citation

Bryushkova L, Zai C, Chen S, Pappa I, Mileva V, Tiemeier H, Bakermans-Kranenburg M, Kennedy JL, Beitchman JH. Psychiatry Res. 2016; 242: 277-280.

Affiliation

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Child, Youth, and Family Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.psychres.2015.09.052

PMID

27315459

Abstract

Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Language: en