Citation

Menschikov PE, Semenova NA, Ublinskiy MV, Akhadov TA, Keshishyan RA, Lebedeva IS, Omelchenko MA, Kaleda VG, Varfolomeev SD. Dokl. Biochem. Biophys. 2016; 468(1): 168-172.

Affiliation

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia.

Copyright

(Copyright © 2016, International Academic Pub. Co)

DOI

10.1134/S1607672916030029

PMID

27417711

Abstract

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.

Language: en