Citation

Sankaranarayanan A, Clark V, Baker A, Palazzi K, Lewin TJ, Richmond R, Kay-Lambkin FJ, Filia S, Castle D, Williams JM. Psychiatry Res. 2016; 243: 407-412.

Affiliation

Division of Addiction Psychiatry, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.psychres.2016.07.006

PMID

27450743

Abstract

This study sought to explore the impact of smoking reduction on suicidality (suicide ideation and behaviour) among people with a psychotic disorder (n=235) who participated in a randomized trial of a healthy lifestyle intervention trial. Suicidality, measured by item -4 of the Brief Psychiatric Rating Scale (BPRS) was the main variable of interest. Measures were collected by research assistants blind to treatment allocation at baseline, at 15 weeks (mid-intervention) and 12 months after baseline. Mediation analysis, adjusted for confounders, was used to determine the relationship between smoking reduction and suicidality and to explore whether this was mediated through depression. At 12 months, smoking reduction was found to be significantly associated with suicidality change; an association was also seen between smoking reduction and depression and depression and suicidality. After adjusting for depression, the association between smoking reduction and suicidality was attenuated but remained statistically significant; the proportion of the total effect that was mediated through depression was 30%. There was no significant association between suicidality and treatment group (vs. controls) over time. Our study suggests that smoking interventions may have benefits over and above those for improved physical health, by reducing suicidal ideation in people with psychosis.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Language: en