Citation

Wang Y, Tang S, Xu S, Weng S, Liu Z. Compr. Psychiatry 2016; 71: 11-16.

Affiliation

Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Department of Psychiatry, Institution of Neuropsychiatry Research, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China. Electronic address: zcliu6@whu.edu.cn.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.comppsych.2016.08.006

PMID

27568823

Abstract

BACKGROUND: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association.

METHODS: We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library up to February 29, 2016 for relevant observational studies regarding the association between diabetes and risk of suicide. Random-effects models were used to calculate summary relative risk (RR) and 95% confidence interval (CI).

RESULTS: 6 observational studies (8 independent reports) with a total of 3,075,214 participants and 3038 suicide deaths events were included in the meta-analysis. Overall, diabetes was not associated with risk of suicide deaths, with significant heterogeneity among studies observed (Summary RR=1.61, 95% CI: 0.91-2.83, Pheterogeneity<0.001, I(2)=97.2%). No publication bias was detected across studies, and both the subgroup analysis and sensitivity analysis suggested that the general result was robust.

CONCLUSION: Our meta-analysis based on more than 3 million participants indicates that diabetes is not associated with increased risk of suicide death. Further well-designed prospective cohort studies are needed to confirm the findings of this meta-analysis.

Copyright © 2016 Elsevier Inc. All rights reserved.

Language: en