CONTACT US: Contact info
|
Citation |
Fratantoni JM, DeLaRosa BL, Didehbani N, Hart J, Kraut MA. J. Neurotrauma 2016; 34(5): 1017-1021. |
|
Affiliation |
The Johns Hopkins University School of Medicine, Radiology, Baltimore, Maryland, United States ; mikekraut@gmail.com. |
|
Copyright |
(Copyright © 2016, Mary Ann Liebert Publishers) |
|
DOI |
|
PMID |
27596052 |
|
Abstract |
Individuals who have suffered a traumatic brain injury (TBI) often have word retrieval deficits; however, the underlying neural mechanisms of such deficits are yet to be clarified. Previous studies in normal subjects have shown that during a word retrieval task, there is a 750 ms event-related potential (ERP) divergence detected at the left fronto-temporal region when subjects evaluate word pairs that facilitate retrieval compared to responses elicited by word pairs that do not facilitate retrieval. In this study, we investigated the neurophysiological correlates of word retrieval networks in 19 retired professional athletes with TBI and 19 healthy controls (HC). We recorded electroencephalography (EEG) in the participants during a semantic object retrieval task (SORT). In this task, participants indicated whether presented word pairs did (retrieval) or did not (non-retrieval) facilitate the retrieval of an object name.There were no significant differences in accuracy or reaction time between the two groups. The EEG showed a significant group by condition interaction over the left-fronto-temporal region. The HC group mean amplitudes were significantly different between conditions, but the TBI group data did not show this difference, suggesting neurophysiological effects of injury. These findings provide evidence that ERP amplitudes may be used as a marker of disrupted semantic retrieval circuits in individuals with TBI even when those people perform normally. Language: en |