AIM: The purpose of current study is to explore the cerebral areas involved in nightmare disorder.
METHODS: Fifteen nightmare disorder patients and 15 healthy volunteers were invited to undergo tests of the resting-state functional magnetic resonance imaging and the Nightmare Experience Questionnaire.
RESULTS: The nightmare disorder patients scored higher on Physical Effect and Horrible Stimulation scales, had higher values of regional homogeneity in clusters within the left anterior cingulate cortex and right inferior parietal lobule, and lower regional homogeneity values within left superior and inferior frontal gyri and bilateral middle occipital gyri. Physical Effect was negatively correlated with regional homogeneity values in anterior cingulate cortex and inferior parietal lobule in the nightmare disorder group, and was positively correlated with regional homogeneity value in inferior frontal gyrus in the healthy control group.
CONCLUSION: To our best knowledge, this is the first neuroimaging study in nightmare disorder, and we have characterized the cerebral activities underlying the altered hyperarousal and emotion regulation in nightmare disorder at resting-state.
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