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Citation
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St Hilaire MA, Rüger M, Fratelli F, Hull JT, Phillips AJ, Lockley SW. Sleep 2018; ePub(ePub): ePub. |
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Abstract
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STUDY OBJECTIVES: Intra-individual night-to-night sleep duration is often insufficient and variable. Here we report the effects of such chronic variable sleep deficiency on neurobehavioral performance and the ability of state-of the-art models to predict these changes.
METHODS: Eight healthy males (mean age ± SD: 23.9 ± 2.4 years) studied on our inpatient intensive physiologic monitoring unit completed an 11-day protocol with a baseline 10-hour sleep opportunity and three cycles of two 3-hour time-in-bed and one 10-hour time-in-bed sleep opportunities. Participants received one of three polychromatic white light interventions (200 lux 4100K, 200 or 400 lux 17000K) for 3.5 hours on the morning following the second 3-hour time-in-bed opportunity each cycle. Neurocognitive performance was assessed using the psychomotor vigilance test (PVT) administered every 1-2 hours. PVT data were compared to predictions of five group-average mathematical models that incorporate chronic sleep loss functions.
RESULTS: While PVT performance deteriorated cumulatively following each cycle of two 3-hour sleep opportunities, and improved following each 10-hour sleep opportunity, performance declined cumulatively throughout the protocol at a more accelerated rate than predicted by state-of-the-art group-average mathematical models. Subjective sleepiness did not reflect performance. The light interventions had minimal effect.
CONCLUSIONS: Despite apparent recovery following each extended sleep opportunity, residual performance impairment remained and deteriorated rapidly when re-challenged with subsequent sleep loss. None of the group-average models were capable of predicting both the build-up in impairment and recovery profile of performance observed at the group or individual level, raising concerns regarding their use in real-world settings to predict performance and improve safety.
Language: en |