Citation

Siddiqui ZF, Krempl G, Spiliopoulou M, Peña JM, Paúl N, Maestú F. Brain Inform. 2015; 2(1): 33-44.

Affiliation

Center for Biomedical Technology, Complutense and Technical University of Madrid, Madrid, Spain.

Copyright

(Copyright © 2015, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s40708-015-0010-6

PMID

27747503

Abstract

Predicting the evolution of individuals is a rather new mining task with applications in medicine. Medical researchers are interested in the progression of a disease and/or how do patients evolve or recover when they are subjected to some treatment. In this study, we investigate the problem of patients' evolution on the basis of medical tests before and after treatment after brain trauma: we want to understand to what extend a patient can become similar to a healthy participant. We face two challenges. First, we have less information on healthy participants than on the patients. Second, the values of the medical tests for patients, even after treatment started, remain well-separated from those of healthy people; this is typical for neurodegenerative diseases, but also for further brain impairments. Our approach encompasses methods for modelling patient evolution and for predicting the health improvement of different patients' subpopulations, i.e. prediction of label if they recovered or not. We test our approach on a cohort of patients treated after brain trauma and a corresponding cohort of controls.

Language: en