Citation

Al Khatib HK, Harding SV, Darzi J, Pot GK. Eur. J. Clin. Nutr. 2016; 71(5): 614-624.

Affiliation

VU University Amsterdam, Health and Life, Faculty of Earth and Life Sciences, Amsterdam, Netherlands.

Copyright

(Copyright © 2016, Nature Publishing Group)

DOI

10.1038/ejcn.2016.201

PMID

27804960

Abstract

BACKGROUND/OBJECTIVES: It is unknown whether short sleep duration causatively contributes to weight gain. Studies investigating effects of partial sleep deprivation (PSD) on energy balance components report conflicting findings. Our objective was to conduct a systematic review and meta-analysis of human intervention studies assessing the effects of PSD on energy intake (EI) and energy expenditure (EE). SUBJECTS/METHODS: EMBASE, Medline, Cochrane CENTRAL, Web of Science and Scopus were searched. Differences in EI and total EE following PSD compared with a control condition were generated using the inverse variance method with random-effects models. Secondary outcomes included macronutrient distribution and resting metabolic rate. Heterogeneity was quantified with the I(2)-statistic.

RESULTS: Seventeen studies (n=496) were eligible for inclusion in the systematic review, and 11 studies (n=172) provided sufficient data to be included in meta-analyses. EI was significantly increased by 385 kcal (95% confidence interval: 252, 517; P<0.00001) following PSD compared with the control condition. We found no significant change in total EE or resting metabolic rate as a result of PSD. The observed increase in EI was accompanied by significantly higher fat and lower protein intakes, but no effect on carbohydrate intake.

CONCLUSIONS: The pooled effects of the studies with extractable data indicated that PSD resulted in increased EI with no effect on EE, leading to a net positive energy balance, which in the long term may contribute to weight gain.European Journal of Clinical Nutrition advance online publication, 2 November 2016; doi:10.1038/ejcn.2016.201.

Language: en