Citation

Galgano M, Toshkezi G, Qiu X, Russell T, Chin L, Zhao LR. Cell Transplant. 2016; ePub(ePub): ePub.

Affiliation

Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.

Copyright

(Copyright © 2016, Cognizant Communication)

DOI

10.3727/096368916X693806

PMID

27938476

Abstract

Traumatic brain injury presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of traumatic brain injury, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of traumatic brain injury, but they must be taken in context of the situation and cannot be used in every individual circumstance. In this review article, we have summarized the current status of treatment for traumatic brain injury in both clinical practice and basic research. We have put forth a brief overview of the various subtypes of traumatic injuries, optimal medical management, as well as both the non-invasive and invasive monitoring modalities, in addition to the surgical interventions necessary in particular instances. We have overviewed the main achievements in searching for therapeutic strategies of traumatic brain injury in basic science. We have also discussed the future direction for developing traumatic brain injury treatment from an experimental perspective.

Language: en