Citation

Acabchuk R, Briggs DI, Angoa-Pérez M, Powers M, Wolferz R, Soloway M, Stern M, Talbot LR, Kuhn DM, Conover JC. Concussion 2016; 1(3): e1.

Affiliation

Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA ; Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA. Author for correspondence: joanne.conover@uconn.edu

Copyright

(Copyright © 2016, The Drake Foundation, Publisher Future Medicine)

DOI

unavailable

PMID

28078102

Abstract

AIM: To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces. MATERIALS & METHODS: A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks).

RESULTS: The rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolateral septum. The rmTBI-long protocol showed only a transitory astroglial response in the dorsolateral septum.

CONCLUSION: Our results indicate that the lateral septum and hippocampus are particularly vulnerable regions in rmTBI, possibly contributing to memory and emotional impairments associated with repeated concussions.

Language: en

Keywords

concussion; gliosis; hippocampus; microglia; mouse model; rmTBI; rotational force; septum